Artificial intelligence and deep learning in ophthalmology.

Journal: The British journal of ophthalmology
Published Date:

Abstract

Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc, macular oedema and age-related macular degeneration. DL in ocular imaging may be used in conjunction with telemedicine as a possible solution to screen, diagnose and monitor major eye diseases for patients in primary care and community settings. Nonetheless, there are also potential challenges with DL application in ophthalmology, including clinical and technical challenges, explainability of the algorithm results, medicolegal issues, and physician and patient acceptance of the AI 'black-box' algorithms. DL could potentially revolutionise how ophthalmology is practised in the future. This review provides a summary of the state-of-the-art DL systems described for ophthalmic applications, potential challenges in clinical deployment and the path forward.

Authors

  • Daniel Shu Wei Ting
    Singapore National Eye Center, Singapore Eye Research Institute Singapore Health Service Singapore Singapore.
  • Louis R Pasquale
    Eye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Lily Peng
    Google Inc, Mountain View, California.
  • John Peter Campbell
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.
  • Aaron Y Lee
    Department of Ophthalmology, University of Washington, Seattle, Washington.
  • Rajiv Raman
    Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
  • Gavin Siew Wei Tan
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Leopold Schmetterer
    Singapore Eye Research Institute, Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
  • Pearse A Keane
    National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Tien Yin Wong
    Singapore National Eye Center, Duke-National University of Singapore Medical School, Singapore 168751, Singapore; National Institutes of Health Research Biomedical Research Centre Biomedical Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.