Deep learning for DNase I hypersensitive sites identification.

Journal: BMC genomics
Published Date:

Abstract

BACKGROUND: The DNase I hypersensitive sites (DHSs) are associated with the cis-regulatory DNA elements. An efficient method of identifying DHSs can enhance the understanding on the accessibility of chromatin. Despite a multitude of resources available on line including experimental datasets and computational tools, the complex language of DHSs remains incompletely understood.

Authors

  • Chuqiao Lyu
    School of Life Science, Beijing Institute of Technology, South Zhongguancun Street, Beijing, 100081, China.
  • Lei Wang
    Department of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Juhua Zhang
    Department of Biomedical Engineering.