Applications of machine learning in decision analysis for dose management for dofetilide.

Journal: PloS one
PMID: 31891645

Abstract

BACKGROUND: Initiation of the antiarrhythmic medication dofetilide requires an FDA-mandated 3 days of telemetry monitoring due to heightened risk of toxicity within this time period. Although a recommended dose management algorithm for dofetilide exists, there is a range of real-world approaches to dosing the medication.

Authors

  • Andrew E Levy
    Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. Andrew.levy@ucdenver.edu.
  • Minakshi Biswas
    Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
  • Rachel Weber
    Division of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, United States of America.
  • Khaldoun Tarakji
    Center for Atrial Fibrillation, Section of Cardiac Pacing and Electrophysiology, Cleveland Clinic Foundation, Cleveland, OH, United States of America.
  • Mina Chung
    Center for Atrial Fibrillation, Section of Cardiac Pacing and Electrophysiology, Cleveland Clinic Foundation, Cleveland, OH, United States of America.
  • Peter A Noseworthy
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
  • Christopher Newton-Cheh
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Michael A Rosenberg
    Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.

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