AIMC Topic: Phenethylamines
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Determination of new psychoactive substances and other drugs in postmortem blood and urine by UHPLC-MS/MS: method validation and analysis of forensic samples.
Forensic toxicology
Oct 5, 2021
PURPOSE: This study aimed to validate a modified QuEChERS method followed by ultra-high performance liquid chromatography-tandem mass spectrometry to determine 79 new psychoactive substances (NPS) and other drugs in blood and urine.
A deep learning algorithm to translate and classify cardiac electrophysiology.
eLife
Jul 2, 2021
The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific physiology, pathophysiology, and pharmacology. We designed a new deep learning multitask network ...
Phenethylamines
Algorithms
Myocytes, Cardiac
Computer Simulation
Induced Pluripotent Stem Cells
Gene Expression Regulation
Models, Biological
Action Potentials
Electrophysiologic Techniques, Cardiac
Electrophysiological Phenomena
Humans
Deep Learning
Sulfonamides
Cell Differentiation
ERG1 Potassium Channel
A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
Nature communications
Jun 7, 2021
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compound...
Applications of machine learning in decision analysis for dose management for dofetilide.
PloS one
Dec 31, 2019
BACKGROUND: Initiation of the antiarrhythmic medication dofetilide requires an FDA-mandated 3 days of telemetry monitoring due to heightened risk of toxicity within this time period. Although a recommended dose management algorithm for dofetilide exi...
Classification of drug-induced hERG potassium-channel block from electrocardiographic T-wave features using artificial neural networks.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Jul 26, 2019
BACKGROUND: Human ether-à-go-go-related gene (hERG) potassium-channel block represents a harmful side effect of drug therapy that may cause torsade de pointes (TdP). Analysis of ventricular repolarization through electrocardiographic T-wave features ...
Determination of ractopamine and salbutamol in pig hair by liquid chromatography tandem mass spectrometry.
Journal of food and drug analysis
Nov 12, 2017
A liquid chromatography tandem mass spectrometric method was developed for the determination of two β-agonists (ractopamine and salbutamol) in pig hair samples. An isotope of ractopamine-d5 or salbutamol-d6 as an internal standard was used to carry o...
[Fluoroimmunoassay and Magnetic Lateral Flow Immunoassay for the Detection of Ractopamine].
Guang pu xue yu guang pu fen xi = Guang pu
Nov 1, 2015
A fluoroimmunoassay based on quantum dots (QDs) and a lateral flow immunoassay system based on the magnetic beads (MB) were constructed to detect ractopamine (RAG) in urine samples. The monoclonal antibody (Ab1) against RAC was conjugated with QDs or...
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