Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.

Journal: Circulation research
Published Date:

Abstract

RATIONALE: Accumulating evidence implicates inflammation in pulmonary arterial hypertension (PAH) and therapies targeting immunity are under investigation, although it remains unknown if distinct immune phenotypes exist.

Authors

  • Andrew J Sweatt
    From the Division of Pulmonary and Critical Care Medicine (A.J.S., M.R.N., R.T.Z.), in the Department of Medicine, Stanford University, CA.
  • Haley K Hedlin
    Quantitative Sciences Unit (H.K.H., V.B.), in the Department of Medicine, Stanford University, CA.
  • Vidhya Balasubramanian
    Quantitative Sciences Unit (H.K.H., V.B.), in the Department of Medicine, Stanford University, CA.
  • Andrew Hsi
    Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, CA (A.J.S., A.H., M.R.N., M.R., R.T.Z.).
  • Lisa K Blum
    Division of Immunology and Rheumatology (L.K.B., W.H.R.), in the Department of Medicine, Stanford University, CA.
  • William H Robinson
    Stanford University School of Medicine, Stanford, California.
  • Francois Haddad
    Division of Cardiovascular Medicine (F.H.), in the Department of Medicine, Stanford University, CA.
  • Peter M Hickey
    Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, United Kingdom (P.M.H., A.L.).
  • Robin Condliffe
    Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, United Kingdom (R.C.).
  • Allan Lawrie
    Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, United Kingdom (P.M.H., A.L.).
  • Mark R Nicolls
    From the Division of Pulmonary and Critical Care Medicine (A.J.S., M.R.N., R.T.Z.), in the Department of Medicine, Stanford University, CA.
  • Marlene Rabinovitch
    Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, CA (A.J.S., A.H., M.R.N., M.R., R.T.Z.).
  • Purvesh Khatri
    Department of Radiation Oncology, Stanford University School of Medicine , Stanford, California 94305, United States.
  • Roham T Zamanian
    From the Division of Pulmonary and Critical Care Medicine (A.J.S., M.R.N., R.T.Z.), in the Department of Medicine, Stanford University, CA.