Effects of combining modern recovery techniques with neurotrophic medication and standard treatment in stroke patients.

Journal: The Science of the total environment
PMID:

Abstract

Stroke is the main cause of disability after age 65, leaving survivors with sequels that require care and recovery treatment lasting years. It is estimated that by the year 2030 this pathology will be leading cause of mortality. To determine the efficacy of Lokomat training combined with neurotrophic medication and balneo-physiotherapeutic treatment in rehabilitation of post-stroke patients, a prospective study of 3 parallel groups was conducted: Group I (n = 22) - Lokomat, balneo-physiotherapy, and Cerebrolysin; Group II (n = 18) - Lokomat associated with balneo-physiotherapy; and Group III (n = 30) - balneo-physiotherapy alone (Control group). Patients were evaluated physically, neurologically, and functionally, according to the evolution of their motor deficiency, spasticity, functional independence and health-related quality of life. Patient improvement is significantly better (p < 0.05) in the group with associated therapies, especially during the first 6 months. Evolution was significantly better in all groups at 12 months than initially (p < 0.05), for all studied parameters and with the best effects in Group I (the three therapies combined). Association of Lokomat training with neurotrophic factors and classic recovery techniques improves the rehabilitation process in stroke patients.

Authors

  • Diana Uivarosan
    Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Delia Mirela Tit
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Ciprian Iovan
    Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Delia Carmen Nistor-Cseppento
    Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Laura Endres
    Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Liviu Lazar
    Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Cristian Sava
    Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Anca Maria Sabau
    Department of Physical Education, Sport and Physical Therapy, Faculty of Geography, Tourism and Sport, University of Oradea, Oradea 410028, Romania.
  • Camelia Buhas
    Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Lavinia Cristina Moleriu
    Department III Functional Sciences, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
  • Simona Bungau
    Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.
  • Lotfi Aleya
    Laboratoire Chrono-environnement, Université de Franche-Comté, Besançon, France. Electronic address: lotfi.aleya@univ-fcomte.fr.