Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease.

Journal: JAMA network open
PMID: 31074823

Abstract

IMPORTANCE: Biological therapies have revolutionized inflammatory bowel disease management, but many patients do not respond to biological monotherapy. Identification of likely responders could reduce costs and delays in remission.

Authors

  • Akbar K Waljee
    VA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, Michigan.
  • Beth I Wallace
    Michigan Integrated Center for Health Analytics and Medical Prediction, Ann Arbor.
  • Shirley Cohen-Mekelburg
    VA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, Michigan.
  • Yumu Liu
    Department of Statistics, University of Michigan, Ann Arbor.
  • Boang Liu
    Department of Statistics, University of Michigan, Ann Arbor, Michigan.
  • Kay Sauder
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
  • Ryan W Stidham
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
  • Ji Zhu
    Department of Statistics, University of Michigan, Ann Arbor, Michigan.
  • Peter D R Higgins
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

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