Computational functional genomics-based reduction of disease-related gene sets to their key components.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jul 15, 2019
Abstract
MOTIVATION: The genetic architecture of diseases becomes increasingly known. This raises difficulties in picking suitable targets for further research among an increasing number of candidates. Although expression based methods of gene set reduction are applied to laboratory-derived genetic data, the analysis of topical sets of genes gathered from knowledge bases requires a modified approach as no quantitative information about gene expression is available.