Rapid detection of α-amanitin and β-amanitin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to the toxicokinetic study of Lepiota brunneoincarnata.

Journal: Forensic toxicology
Published Date: Dec 1, 2021

Abstract

PURPOSE: Lepiota brunneoincarnata is a well-known poisonous mushroom and is responsible for fatal mushroom poisoning cases worldwide. α-Amanitin and β-amanitin are the main amatoxin compounds of Lepiota brunneoincarnata. However, there are no published toxicokinetic studies of Lepiota brunneoincarnata. To study the toxicokinetics of Lepiota brunneoincarnata, we developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for determination of α-amanitin and β-amanitin in rat plasma.

Authors

  • Zhengsheng Mao
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China. maozhengsheng@njmu.edu.cn.
  • Youjia Yu
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Hao Sun
    Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
  • Yue Cao
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Qiaoyan Jiang
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Chunyan Chu
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Yang Sun
    Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Shuainan Huang
    Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
  • Jinsong Zhang
    Department of Emergency, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China. zhangjso@njmu.edu.cn.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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