Human and rat microsomal metabolites of N-tert-butoxycarbonylmethamphetamine and its urinary metabolites in rat.

Journal: Forensic toxicology
PMID: 36454489

Abstract

PURPOSE: N-tert-Butoxycarbonylmethamphetamine (BocMA), a masked derivative of methamphetamine (MA), converts into MA under acidic condition and potentially acts as a precursor to MA following ingestion. To investigate the metabolism and excretion of BocMA, metabolism tests were conducted using human liver microsomes (HLM), rat liver microsomes (RLM) and rat.

Authors

  • Hidenao Kakehashi
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan. k.hidenao7140@gmail.com.
  • Takahiro Doi
    Osaka Institute of Public Health Division of Hygienic Chemistry, Osaka, Japan.
  • Misato Wada
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Tooru Kamata
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Noriaki Shima
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Akari Miyake
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Atsushi Nitta
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Ryutaro Asai
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Shihoko Fujii
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Shuntaro Matsuta
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Keiko Sasaki
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Hiroe Kamata
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Hiroshi Nishioka
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Akihiro Miki
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.
  • Hiroshi Hasegawa
    Laboratory of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higasinada-ku, Kobe, Hyogo, 658-8558, Japan.
  • Munehiro Katagi
    Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka, 541-0053, Japan.

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