Machine learning-based identification and rule-based normalization of adverse drug reactions in drug labels.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: Use of medication can cause adverse drug reactions (ADRs), unwanted or unexpected events, which are a major safety concern. Drug labels, or prescribing information or package inserts, describe ADRs. Therefore, systematically identifying ADR information from drug labels is critical in multiple aspects; however, this task is challenging due to the nature of the natural language of drug labels.

Authors

  • Mert Tiftikci
    Department of Computer Engineering, Boğaziçi University, İstanbul, 34342, Turkey.
  • Arzucan Özgür
  • Yongqun He
    University of Michigan Medical School, Ann Arbor, MI 48109 USA ; Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, 1301 MSRB III, 1150 W. Medical Dr., Ann Arbor, MI 48109 USA.
  • Junguk Hur
    School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203 USA.