Journal of computer-aided molecular design
Oct 24, 2025
Accurate prediction of a drug molecule's toxicity is a critical step in pharmaceutical research, offering the potential to reduce experimental costs, mitigate adverse effects, and accelerate drug development. Traditional computational methods often r...
Adverse drug reactions (ADRs) remain a major, yet largely preventable, global public health challenge, causing significant morbidity, mortality, and healthcare costs. This review synthesises evidence on the global burden, pharmacovigilance systems, a...
BACKGROUND: Drug-drug interactions (DDIs) are a major concern, especially for older adults taking multiple medications. Although Health Canada and the US Food and Drug Administration (FDA) use population-based studies to identify adverse drug events,...
Journal of chemical information and modeling
Sep 17, 2025
Drug side effects increase morbidity and mortality in the relevant medical fields. Assessing the frequency of drug side effects is crucial for drug development and risk-effect analysis. Most current research approaches focus on modeling heterogeneous...
BACKGROUND: Adverse drug reactions (ADR) present significant challenges in health care, where early prevention is vital for effective treatment and patient safety. Traditional supervised learning methods struggle to address heterogeneous health care ...
Journal of chemical information and modeling
Aug 19, 2025
Nephrotoxicity remains a critical safety concern in drug development and clinical practice. Despite their significance, existing computational models for nephrotoxicity prediction face challenges related to limited precision and reliability. To addre...
Large language models (LLMs) are useful tools with the capacity for performing specific types of knowledge work at an effective scale. However, LLM deployments in high-risk and safety-critical domains pose unique challenges, notably the issue of "hal...
Immunotherapy, in particular checkpoint blockade, has revolutionized the treatment of many advanced cancers. Imaging plays a critical role in assessing both treatment response and the development of immune toxicities. Both conventional imaging and mo...
BMC medical informatics and decision making
Jul 15, 2025
BACKGROUND: Drug-induced immune thrombocytopenia (DITP) is a rare but potentially life-threatening adverse drug reaction, often underrecognized due to its nonspecific presentation and the lack of real-time diagnostic tools. Early identification of at...
Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis). Patients who could benefit from clozapin...
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