CHDGKB: a knowledgebase for systematic understanding of genetic variations associated with non-syndromic congenital heart disease.

Journal: Database : the journal of biological databases and curation
Published Date: Jan 1, 2020

Abstract

Congenital heart disease (CHD) is one of the most common birth defects, with complex genetic and environmental etiologies. The reports of genetic variation associated with CHD have increased dramatically in recent years due to the revolutionary development of molecular technology. However, CHD is a heterogeneous disease, and its genetic origins remain inconclusive in most patients. Here we present a database of genetic variations for non-syndromic CHD (NS-CHD). By manually literature extraction and analyses, 5345 NS-CHD-associated genetic variations were collected, curated and stored in the public online database. The objective of our database is to provide the most comprehensive updates on NS-CHD genetic research and to aid systematic analyses of pathogenesis of NS-CHD in molecular level and the correlation between NS-CHD genotypes and phenotypes. Database URL: http://www.sysbio.org.cn/CHDGKB/.

Authors

  • Lan Yang
    The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #7 Jinsui Road, Guangzhou, Guangdong 510230, China.
  • Yang Yang
    Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
  • Xingyun Liu
    Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610212, Sichuan, China; Center for Systems Biology, Soochow University, Suzhou 215006, Jiangsu, China.
  • Yongquan Chen
    School of Computer Science and Technology, Soochow University, Suzhou 215006, China.
  • Yalan Chen
    Center for Systems Biology, Soochow University, Suzhou 215006, China.
  • Yuxin Lin
    School of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, China.
  • Yan Sun
    Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, United States.
  • Bairong Shen
    Institute of Systems Genetics, Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, China.

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