Machine learning insight into the role of imaging and clinical variables for the prediction of obstructive coronary artery disease and revascularization: An exploratory analysis of the CONSERVE study.

Journal: PloS one
PMID:

Abstract

BACKGROUND: Machine learning (ML) is able to extract patterns and develop algorithms to construct data-driven models. We use ML models to gain insight into the relative importance of variables to predict obstructive coronary artery disease (CAD) using the Coronary Computed Tomographic Angiography for Selective Cardiac Catheterization (CONSERVE) study, as well as to compare prediction of obstructive CAD to the CAD consortium clinical score (CAD2). We further perform ML analysis to gain insight into the role of imaging and clinical variables for revascularization.

Authors

  • Lohendran Baskaran
  • Xiaohan Ying
    Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine, New York, New York, United States of America.
  • Zhuoran Xu
    1 Dalio Institute of Cardiovascular Imaging New York-Presbyterian Hospital New York NY.
  • Subhi J Al'Aref
    Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine, New York, USA.
  • Benjamin C Lee
    Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine, New York, New York.
  • Sang-Eun Lee
    Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea - selee@snubh.org.
  • Ibrahim Danad
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Hyung-Bok Park
    Myongji Hospital, Seonam University College of Medicine, Gyeonggi-do, South Korea.
  • Ravi Bathina
    CARE Hospital and FACTS Foundation, Hyderabad, India.
  • Andrea Baggiano
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Virginia Beltrama
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  • Rodrigo Cerci
    Quanta Diagnostico Nuclear, Curitiba, Brazil.
  • Eui-Young Choi
    Gangnam Severance Hospital, Seoul, South Korea.
  • Jung-Hyun Choi
    Pusan National University Hospital, Busan, South Korea.
  • So-Yeon Choi
    Department of Cardiology, Ajou University, Suwon, Korea.
  • Jason Cole
    Cardiology Associates of Mobile, Mobile, Alabama, United States of America.
  • Joon-Hyung Doh
    Inje University, Ilsan Paik Hospital, Gyeonggi-do, South Korea.
  • Sang-Jin Ha
    Gangneung Asan Hospital, Gangwon-do, South Korea.
  • Ae-Young Her
    Kangwon National University Hospital, Gangwon-do, South Korea.
  • Cezary Kepka
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Coronary Disease and Structural Heart Diseases Department, Institute of Cardiology, Warsaw, Poland (M.K., C.K.).
  • Jang-Young Kim
    Wonju Severance Hospital, Gangwon-do, South Korea.
  • Jin-Won Kim
    Korea University Guro Hospital, Seoul, South Korea.
  • Sang-Wook Kim
    Chung-Ang University Hospital, Seoul, South Korea.
  • Woong Kim
    Yeungnam University Hospital, Daegu, South Korea.
  • Yao Lu
    Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo First Hospital, Ningbo, China.
  • Amit Kumar
    Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.
  • Ran Heo
    Division of Cardiology, Severance Cardiovascular Hospital, Seoul, Korea. Electronic address: cardiohr@yuhs.ac.
  • Ji Hyun Lee
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Republic of Korea.
  • Ji-Min Sung
    Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea.
  • Uma Valeti
    Department of Medicine, Stanford Medicine, Stanford, California, United States of America.
  • Daniele Andreini
    Division of Cardiology and Cardiac Imaging, IRCCS Ospedale Galeazzi - Sant'Ambrogio Milan, Italy.
  • Gianluca Pontone
    Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Donghee Han
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Republic of Korea.
  • Todd C Villines
    Cardiology Service, Walter Reed National Military Center, Bethesda, MD, USA.
  • Fay Lin
    Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine, New York, New York; Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, New York.
  • Hyuk-Jae Chang
    Department of Cardiology, Yonsei University College of Medicine, Seoul, Republic Of Korea.
  • James K Min
    3 Department of Radiology, Weill Cornell Medicine , New York, New York.
  • Leslee J Shaw
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.