AIMC Topic: Coronary Artery Disease

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Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.

Cardiovascular diabetology Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Middle Aged Risk Assessment Severity of Illness Index Epigenesis, Genetic Machine Learning Female Biomarkers Prognosis Reproducibility of Results Humans Predictive Value of Tests Aged Inflammation Male ST Elevation Myocardial Infarction DNA Methylation Cell-Free Nucleic Acids Non-ST Elevated Myocardial Infarction Coronary Artery Disease Inflammation Mediators 5-Methylcytosine
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A multimodal dataset for coronary microvascular disease biomarker discovery.

Scientific data Jun 12, 2025
Coronary microvascular disease (CMD), particularly prevalent among women, is associated with increased morbidity and mortality, making clinical screening vital for effective management. However, limited publicly available screening-level data hinders...
Humans Machine Learning Biomarkers Female Coronary Artery Disease Aged Middle Aged Electrocardiography Positron Emission Tomography Computed Tomography
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A plaque recognition algorithm for coronary OCT images by Dense Atrous Convolution and attention mechanism.

PloS one Jun 10, 2025
Currently, plaque segmentation in Optical Coherence Tomography (OCT) images of coronary arteries is primarily carried out manually by physicians, and the accuracy of existing automatic segmentation techniques needs further improvement. To furnish eff...
Image Processing, Computer-Assisted Tomography, Optical Coherence Coronary Artery Disease Coronary Vessels Plaque, Atherosclerotic Humans Algorithms Deep Learning
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Comparative analysis of machine learning models for coronary artery disease prediction with optimized feature selection.

International journal of cardiology May 31, 2025
BACKGROUND: Coronary artery disease (CAD) is a major global cause of death, necessitating early, accurate prediction for better management. Traditional diagnostics are often invasive, costly, and less accessible. Machine learning (ML) offers a non-in...
Male Middle Aged Predictive Value of Tests Coronary Artery Disease Machine Learning Databases, Factual Female Aged Humans
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Divergent Immune Pathways in Coronary Artery Disease and Aortic Stenosis: The Role of Chronic Inflammation and Senescence.

International journal of molecular sciences May 29, 2025
Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality, with growing evidence linking immune dysregulation to its pathogenesis. Aortic stenosis often coexists with CAD (ASCAD), representing an advanced disease f...
Aortic Valve Stenosis Coronary Artery Disease Immunosenescence Humans Cytokines Biomarkers Male Middle Aged Inflammation Female Aged
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Two birds with one stone: pre-TAVI coronary CT angiography combined with FFR helps screen for coronary stenosis.

BMC medical imaging May 26, 2025
OBJECTIVES: Since coronary artery disease (CAD) is a common comorbidity in patients with aortic valve stenosis, invasive coronary angiography (ICA) can be avoided if significant CAD can be screened with the non-invasive coronary CT angiography (cCTA)...
Humans Machine Learning Retrospective Studies Transcatheter Aortic Valve Replacement Female Coronary Artery Disease Aged Computed Tomography Angiography Aged, 80 and over Male Coronary Stenosis Sensitivity and Specificity Aortic Valve Stenosis Fractional Flow Reserve, Myocardial Predictive Value of Tests Coronary Angiography
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Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Nature communications May 15, 2025
Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditiona...
Platelet Aggregation Humans Coronary Artery Disease Female Acute Coronary Syndrome Blood Platelets Platelet Aggregation Inhibitors Aged Male Middle Aged Deep Learning
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Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.

Journal of translational medicine May 9, 2025
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
Male Humans Coronary Artery Disease Foam Cells Biomarkers Cell Hypoxia Middle Aged Female Myocytes, Smooth Muscle Case-Control Studies Aged Guanine Nucleotide Exchange Factors ROC Curve
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Fast and automatic coronary artery segmentation using nnU-Net for non-contrast enhanced magnetic resonance coronary angiography.

The international journal of cardiovascular imaging Apr 26, 2025
Non-contrast enhanced magnetic resonance coronary angiography (MRCA) is a promising coronary heart disease screening modality. However, its clinical application is hindered by inherent limitations, including low spatial resolution and insufficient co...
Predictive Value of Tests Coronary Angiography Coronary Artery Disease Image Interpretation, Computer-Assisted Male Middle Aged Deep Learning Time Factors Computed Tomography Angiography Observer Variation Automation Coronary Vessels Magnetic Resonance Angiography Humans Female Reproducibility of Results Aged
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Optimising coronary imaging decisions with machine learning: an external validation study.

Open heart Apr 24, 2025
BACKGROUND: Exclusion of coronary stenosis in individuals with suggestive symptoms is challenging. Cardiac CT or coronary angiography is often used but is inefficient and costly and involves risks. Sex-stratified algorithms based on electronic health...
Aged Male Middle Aged Predictive Value of Tests Retrospective Studies Electronic Health Records Female Reproducibility of Results Coronary Vessels Computed Tomography Angiography Coronary Stenosis Coronary Angiography Coronary Artery Disease Netherlands Sex Factors Humans Machine Learning Algorithms
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