Deep representation learning for domain adaptable classification of infrared spectral imaging data.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: Applying infrared microscopy in the context of tissue diagnostics heavily relies on computationally preprocessing the infrared pixel spectra that constitute an infrared microscopic image. Existing approaches involve physical models, which are non-linear in nature and lead to classifiers that do not generalize well, e.g. across different types of tissue preparation. Furthermore, existing preprocessing approaches involve iterative procedures that are computationally demanding, so that computation time required for preprocessing does not keep pace with recent progress in infrared microscopes which can capture whole-slide images within minutes.

Authors

  • Arne P Raulf
    Center for Protein Diagnostics (ProDi), 44801 Bochum, Germany.
  • Joshua Butke
    Center for Protein Diagnostics (ProDi), 44801 Bochum, Germany.
  • Claus Küpper
    Center for Protein Diagnostics (ProDi), 44801 Bochum, Germany.
  • Frederik Großerueschkamp
    Center for Protein Diagnostics (ProDi), 44801 Bochum, Germany.
  • Klaus Gerwert
    Department of Biophysics, Ruhr-University Bochum, Bochum, Germany.
  • Axel Mosig
    Department of Biophysics, Ruhr-University Bochum, Bochum, Germany.