Improving lipid mapping in Genome Scale Metabolic Networks using ontologies.

Journal: Metabolomics : Official journal of the Metabolomic Society
PMID: 32215752

Abstract

INTRODUCTION: To interpret metabolomic and lipidomic profiles, it is necessary to identify the metabolic reactions that connect the measured molecules. This can be achieved by putting them in the context of genome-scale metabolic network reconstructions. However, mapping experimentally measured molecules onto metabolic networks is challenging due to differences in identifiers and level of annotation between data and metabolic networks, especially for lipids.

Authors

  • Nathalie Poupin
    UMR1331, Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300, Toulouse, France.
  • Florence Vinson
    UMR1331, Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300, Toulouse, France.
  • Arthur Moreau
    UMR1331, Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300, Toulouse, France.
  • Aurélie Batut
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Maxime Chazalviel
    MedDay Pharmaceuticals, Paris, France.
  • Benoit Colsch
    Université Paris Saclay, CEA, INRAE, Médicaments Et Technologies Pour La santé (MTS), 91191, Gif-sur-Yvette, France.
  • Laetitia Fouillen
    Université de Bordeaux, CNRS, Laboratoire de Biogenèse Membranaire, UMR 5200, 33140, Villenave d'Ornon, France.
  • Sarah Guez
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Spiro Khoury
    Université Clermont Auvergne, INRAE, UNH, Plateforme d'Exploration du Métabolisme, MetaboHUB Clermont, 63000, Clermont-Ferrand, France.
  • Jessica Dalloux-Chioccioli
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Anthony Tournadre
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Pauline Le Faouder
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Corinne Pouyet
    Université Clermont Auvergne, INRAE, UNH, Plateforme d'Exploration du Métabolisme, MetaboHUB Clermont, 63000, Clermont-Ferrand, France.
  • Pierre Van Delft
    Université de Bordeaux, CNRS, Laboratoire de Biogenèse Membranaire, UMR 5200, 33140, Villenave d'Ornon, France.
  • Fanny Viars
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France.
  • Justine Bertrand-Michel
    MetaToul-Lipidomic Core Facility, MetaboHUB, Inserm I2MC, 31000, Toulouse, France. justine.bertrand-michel@inserm.fr.
  • Fabien Jourdan
    UMR1331, Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300, Toulouse, France. Fabien.Jourdan@inrae.fr.

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