Graph embedding on biomedical networks: methods, applications and evaluations.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: Graph embedding learning that aims to automatically learn low-dimensional node representations, has drawn increasing attention in recent years. To date, most recent graph embedding methods are evaluated on social and information networks and are not comprehensively studied on biomedical networks under systematic experiments and analyses. On the other hand, for a variety of biomedical network analysis tasks, traditional techniques such as matrix factorization (which can be seen as a type of graph embedding methods) have shown promising results, and hence there is a need to systematically evaluate the more recent graph embedding methods (e.g. random walk-based and neural network-based) in terms of their usability and potential to further the state-of-the-art.

Authors

  • Xiang Yue
    Department of Computer Science and Engineering, The Ohio State University, Columbus, United States of America.
  • Zhen Wang
    Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, Guangdong, China.
  • Jingong Huang
    Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, USA.
  • Srinivasan Parthasarathy
    Department of Biomedical Informatics, the Department of Computer Science and Engineering, and the Translational Data Analytics Institute, The Ohio State University, Columbus, OH, 43210.
  • Soheil Moosavinasab
  • Yungui Huang
    Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Simon M Lin
    Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH 43215. Email: Simon.Lin@nationwidechildrens.org.
  • Wen Zhang
    Oil Crops Research Institute, Chinese Academy of Agricultural Sciences Wuhan 430062 China peiwuli@oilcrops.cn zhangqi521x@126.com +86-27-8681-2943 +86-27-8671-1839.
  • Ping Zhang
    Department of Computer Science and Engineering, The Ohio State University, USA.
  • Huan Sun
    Department of Computer Science and Engineering, OH, USA.