FF-QuantSC: accurate quantification of fetal fraction by a neural network model.

Journal: Molecular genetics & genomic medicine
PMID: 32281746

Abstract

BACKGROUND: Noninvasive prenatal testing (NIPT) is one of the most commonly employed clinical measures for screening of fetal aneuploidy. Fetal Fraction (ff) has been demonstrated to be one of the key factors affecting the performance of NIPT. Accurate quantification of ff plays vital role in NIPT.

Authors

  • Yuying Yuan
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Xianghua Chai
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Na Liu
  • Bida Gu
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Shengting Li
    BGI-Shenzhen, Shenzhen, Guangdong, 518083, China.
  • Ya Gao
    BGI-Shenzhen, Shenzhen, China.
  • Lijun Zhou
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Qiang Liu
    Blood Transfusion Laboratory, Jiangxi Provincial Blood Center Nanchang 330052, Jiangxi, China.
  • Fan Yang
    School of Electrical Engineering and Automation, Jiangsu Normal University, Xuzhou, China.
  • Jingjuan Liu
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Jiao Qiu
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Jinjin Zhang
    National Clinical Research Center for Obstetrical and Gynecological Diseases Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
  • Yumei Hou
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Miaolan Cen
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Zhongming Tian
    Tianjin Medical Laboratory, BGI-Tianjin, BGI-Shenzhen, Tianjin, China.
  • Weijiang Tang
    BGI-Wuhan Clinical Laboratories, BGI-Shenzhen, Wuhan, China.
  • Hongyun Zhang
    Clinical laboratory of BGI Health, BGI-Shenzhen, Shenzhen, China.
  • Fang Chen
  • Ye Yin
    BGI Genomics, BGI-Shenzhen, Shenzhen, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.

Keywords

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