Machine learning techniques for biomedical image segmentation: An overview of technical aspects and introduction to state-of-art applications.

Journal: Medical physics
Published Date:

Abstract

In recent years, significant progress has been made in developing more accurate and efficient machine learning algorithms for segmentation of medical and natural images. In this review article, we highlight the imperative role of machine learning algorithms in enabling efficient and accurate segmentation in the field of medical imaging. We specifically focus on several key studies pertaining to the application of machine learning methods to biomedical image segmentation. We review classical machine learning algorithms such as Markov random fields, k-means clustering, random forest, etc. Although such classical learning models are often less accurate compared to the deep-learning techniques, they are often more sample efficient and have a less complex structure. We also review different deep-learning architectures, such as the artificial neural networks (ANNs), the convolutional neural networks (CNNs), and the recurrent neural networks (RNNs), and present the segmentation results attained by those learning models that were published in the past 3 yr. We highlight the successes and limitations of each machine learning paradigm. In addition, we discuss several challenges related to the training of different machine learning models, and we present some heuristics to address those challenges.

Authors

  • Hyunseok Seo
    Medical Physics Division in the Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA, 94305-5847, USA.
  • Masoud Badiei Khuzani
    Medical Physics Division in the Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA, 94305-5847, USA.
  • Varun Vasudevan
    Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA, 94305-5847, USA.
  • Charles Huang
    Department of Electrical Engineering, Stanford University, Stanford, California.
  • Hongyi Ren
    Medical Physics Division in the Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA, 94305-5847, USA.
  • Ruoxiu Xiao
    Medical Physics Division in the Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA, 94305-5847, USA.
  • Xiao Jia
    School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, People's Republic of China. School of Software Engineering, Nanyang Normal University, Nanyang, Henan 473061, People's Republic of China. Guangzhou Key Laboratory of Medical Radiation Imaging and Detection Technology, Southern Medical University, Guangzhou, Guangdong 510515, People's Republic of China.
  • Lei Xing
    Department of Radiation Oncology, Stanford University, CA, USA.