Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices.

Journal: JCO clinical cancer informatics
Published Date: Jul 1, 2020

Abstract

PURPOSE: The cancer research community is constantly evolving to better understand tumor biology, disease etiology, risk stratification, and pathways to novel treatments. Yet the clinical cancer genomics field has been hindered by redundant efforts to meaningfully collect and interpret disparate data types from multiple high-throughput modalities and integrate into clinical care processes. Bespoke data models, knowledgebases, and one-off customized resources for data analysis often lack adequate governance and quality control needed for these resources to be clinical grade. Many informatics efforts focused on genomic interpretation resources for neoplasms are underway to support data collection, deposition, curation, harmonization, integration, and analytics to support case review and treatment planning.

Authors

  • Shruti Rao
    Innovation Center For Biomedical Informatics, Georgetown University, Washington D.C, United States of America.
  • Beth Pitel
    Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • Alex H Wagner
    McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Simina M Boca
    Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.
  • Matthew McCoy
    Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC.
  • Ian King
    Laboratory Medicine Program, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Samir Gupta
    Department of Computer and Information Sciences, University of Delaware, Newark, DE, 19711, USA. sgupta@udel.edu.
  • Ben Ho Park
    Division of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.
  • Jeremy L Warner
    Department of Medicine, Brown University, Providence, RI, 02912, United States.
  • James Chen
    Department of Physical Therapy.
  • Peter K Rogan
    Department of Biochemistry, Schulich School of Medicine and Dentistry University of Western Ontario, London, Canada N6A 2C8 Canada.
  • Debyani Chakravarty
    Kravis Center of Molecular Oncology, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Malachi Griffith
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Obi L Griffith
    The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Subha Madhavan
    Innovation Center For Biomedical Informatics, Georgetown University, Washington D.C, United States of America.

Keywords

External Resources

Popular Topics
Recent Journals