Radiomics for Gleason Score Detection through Deep Learning.

Journal: Sensors (Basel, Switzerland)
Published Date:

Abstract

Prostate cancer is classified into different stages, each stage is related to a different Gleason score. The labeling of a diagnosed prostate cancer is a task usually performed by radiologists. In this paper we propose a deep architecture, based on several convolutional layers, aimed to automatically assign the Gleason score to Magnetic Resonance Imaging (MRI) under analysis. We exploit a set of 71 radiomic features belonging to five categories: First Order, Shape, Gray Level Co-occurrence Matrix, Gray Level Run Length Matrix and Gray Level Size Zone Matrix. The radiomic features are gathered directly from segmented MRIs using two free-available dataset for research purpose obtained from different institutions. The results, obtained in terms of accuracy, are promising: they are ranging between 0.96 and 0.98 for Gleason score prediction.

Authors

  • Luca Brunese
    Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
  • Francesco Mercaldo
    Institute for Informatics and Telematics, National Research Council of Italy (CNR), Pisa, Italy; Department of Biosciences and Territory, University of Molise, Pesche (IS), Italy. Electronic address: francesco.mercaldo@iit.cnr.it.
  • Alfonso Reginelli
    Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Napoli, Italy.
  • Antonella Santone
    Department of Biosciences and Territory, University of Molise, Pesche (IS), Italy.