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Neoplasm Grading

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Does artificial intelligence redefine nuclear-to-cytoplasmic ratio threshold for diagnosing high-grade urothelial carcinoma?

Cancer cytopathology
BACKGROUND: The Paris System (TPS) introduced standardized nuclear-to-cytoplasmic (N/C) ratio thresholds for urine cytology to improve high-grade urothelial carcinoma (HGUC) detection, but these criteria remain subjective. This study used AIxURO, an ...

Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine ...

A novel framework for esophageal cancer grading: combining CT imaging, radiomics, reproducibility, and deep learning insights.

BMC gastroenterology
OBJECTIVE: This study aims to create a reliable framework for grading esophageal cancer. The framework combines feature extraction, deep learning with attention mechanisms, and radiomics to ensure accuracy, interpretability, and practical use in tumo...

Ensemble learning guided survival prediction and chemotherapy benefit analysis in high-grade chondrosarcoma: A study based on the surveillance, epidemiology, and end results (SEER) database.

Journal of orthopaedic surgery (Hong Kong)
The chemotherapy benefit for high-grade chondrosarcoma remains controversial. Ensemble learning has better overall performance than single computational approaches for clinical decision. The primary objective was to select prognostic variables and d...

Effective reduction of unnecessary biopsies through a deep-learning-assisted aggressive prostate cancer detector.

Scientific reports
Despite being one of the most prevalent cancers, prostate cancer (PCa) shows a significantly high survival rate, provided there is timely detection and treatment. Currently, several screening and diagnostic tests are required to be carried out in ord...

F-FDG PET/CT-based deep learning models and a clinical-metabolic nomogram for predicting high-grade patterns in lung adenocarcinoma.

BMC medical imaging
BACKGROUND: To develop and validate deep learning (DL) and traditional clinical-metabolic (CM) models based on 18 F-FDG PET/CT images for noninvasively predicting high-grade patterns (HGPs) of invasive lung adenocarcinoma (LUAD).

Artificial intelligence based vision transformer application for grading histopathological images of oral epithelial dysplasia: a step towards AI-driven diagnosis.

BMC cancer
BACKGROUND: This study aimed to classify dysplastic and healthy oral epithelial histopathological images, according to WHO and binary grading systems, using the Vision Transformer (ViT) deep learning algorithm-a state-of-the-art Artificial Intelligen...

Enhanced hierarchical attention mechanism for mixed MIL in automatic Gleason grading and scoring.

Scientific reports
Segmenting histological images and analyzing relevant regions are crucial for supporting pathologists in diagnosing various diseases. In prostate cancer diagnosis, Gleason grading and scoring relies on the recognition of different patterns in tissue ...

An MRI-based deep transfer learning radiomics nomogram for predicting meningioma grade.

Scientific reports
The aim of this study was to establish a nomogram based on clinical, radiomics, and deep transfer learning (DTL) features to predict meningioma grade. Three hundred forty meningiomas from one hospital composed the training set, and 102 meningiomas fr...

Machine learning for grading prediction and survival analysis in high grade glioma.

Scientific reports
We developed and validated a magnetic resonance imaging (MRI)-based radiomics model for the classification of high-grade glioma (HGG) and determined the optimal machine learning (ML) approach. This retrospective analysis included 184 patients (59 gra...