Automatic segmentation, classification, and follow-up of optic pathway gliomas using deep learning and fuzzy c-means clustering based on MRI.

Journal: Medical physics
Published Date:

Abstract

PURPOSE: Optic pathway gliomas (OPG) are low-grade pilocytic astrocytomas accounting for 3-5% of pediatric intracranial tumors. Accurate and quantitative follow-up of OPG using magnetic resonance imaging (MRI) is crucial for therapeutic decision making, yet is challenging due to the complex shape and heterogeneous tissue pattern which characterizes these tumors. The aim of this study was to implement automatic methods for segmentation and classification of OPG and its components, based on MRI.

Authors

  • Moran Artzi
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Sapir Gershov
    The Iby and Aladar, Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 6997801, Israel.
  • Liat Ben-Sira
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6997801, Israel.
  • Jonathan Roth
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6997801, Israel.
  • Danil Kozyrev
    Department of Pediatric Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel.
  • Ben Shofty
    Division of Neurosurgery, Tel Aviv Sourasky Medical Center, 6 Weizman St., 64239, Tel Aviv, Israel.
  • Tomer Gazit
    Functional Brain Center.
  • Tali Halag-Milo
    Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel.
  • Shlomi Constantini
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6997801, Israel.
  • Dafna Ben Bashat
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. dafnab@tlvmc.gov.il.