Deep learning for the prediction of treatment response in depression.

Journal: Journal of affective disorders
Published Date:

Abstract

BACKGROUND: Mood disorders are characterized by heterogeneity in severity, symptoms and treatment response. The possibility of selecting the correct therapy on the basis of patient-specific biomarker may be a considerable step towards personalized psychiatry. Machine learning methods are gaining increasing popularity in the medical field. Once trained, the possibility to consider single patients in the analyses instead of whole groups makes them particularly appealing to investigate treatment response. Deep learning, a branch of machine learning, lately gained attention, due to its effectiveness in dealing with large neuroimaging data and to integrate them with clinical, molecular or -omics biomarkers.

Authors

  • Letizia Squarcina
    UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Italy; InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy.
  • Filippo Maria Villa
    Scientific Institute, IRCCS E. Medea, Developmental Psychopathology Unit, Bosisio Parini, Lecco, Italy.
  • Maria Nobile
  • Enrico Grisan
    Department of Information Engineering, University of Padova, Padova, Italy.
  • Paolo Brambilla
    Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, TX, USA. Electronic address: paolo.brambilla1@unimi.it.