Template-based prediction of protein structure with deep learning.
Journal:
BMC genomics
Published Date:
Dec 29, 2020
Abstract
BACKGROUND: Accurate prediction of protein structure is fundamentally important to understand biological function of proteins. Template-based modeling, including protein threading and homology modeling, is a popular method for protein tertiary structure prediction. However, accurate template-query alignment and template selection are still very challenging, especially for the proteins with only distant homologs available.