The LEukemia Artificial Intelligence Program (LEAP) in chronic myeloid leukemia in chronic phase: A model to improve patient outcomes.

Journal: American journal of hematology
PMID: 33180322

Abstract

Extreme gradient boosting methods outperform conventional machine-learning models. Here, we have developed the LEukemia Artificial intelligence Program (LEAP) with the extreme gradient boosting decision tree method for the optimal treatment recommendation of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia in chronic phase (CML-CP). A cohort of CML-CP patients was randomly divided into training/validation (N = 504) and test cohorts (N = 126). The training/validation cohort was used for 3-fold cross validation to develop the LEAP CML-CP model using 101 variables at diagnosis. The test cohort was then applied to the LEAP CML-CP model and an optimum TKI treatment was suggested for each patient. The area under the curve in the test cohort was 0.81899.Backward multivariate analysis identified age at diagnosis, the degree of comorbidities, and TKI recommended therapy by the LEAP CML-CP model as independent prognostic factors for overall survival. The bootstrapping method internally validated the association of the LEAP CML-CP recommendation with overall survival as an independent prognostic for overall survival. Selecting treatment according to the LEAP CML-CP personalized recommendations, in this model, is associated with better survival probability compared to treatment with a LEAP CML-CP non-recommended therapy. This approach may pave a way of new era of personalized treatment recommendations for patients with cancer.

Authors

  • Koji Sasaki
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Elias J Jabbour
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Farhad Ravandi
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Marina Konopleva
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Gautam Borthakur
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • William G Wierda
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Naval Daver
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Koichi Takahashi
    Department of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.
  • Kiran Naqvi
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Courtney DiNardo
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Guillermo Montalban-Bravo
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Rashmi Kanagal-Shamanna
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Ghayas Issa
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Preetesh Jain
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Jeffrey Skinner
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Mary B Rios
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Sherry Pierce
    Department of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.
  • Kelly A Soltysiak
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Junya Sato
    Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
  • Guillermo Garcia-Manero
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Jorge E Cortes
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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