Deep-learning method for data association in particle tracking.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: Biological studies of dynamic processes in living cells often require accurate particle tracking as a first step toward quantitative analysis. Although many particle tracking methods have been developed for this purpose, they are typically based on prior assumptions about the particle dynamics, and/or they involve careful tuning of various algorithm parameters by the user for each application. This may make existing methods difficult to apply by non-expert users and to a broader range of tracking problems. Recent advances in deep-learning techniques hold great promise in eliminating these disadvantages, as they can learn how to optimally track particles from example data.

Authors

  • Yao Yao
    Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
  • Ihor Smal
    Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Ilya Grigoriev
    Division of Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584CH, The Netherlands.
  • Anna Akhmanova
    Division of Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584CH, The Netherlands.
  • Erik Meijering
    Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.