A deep learning approach to the screening of malaria infection: Automated and rapid cell counting, object detection and instance segmentation using Mask R-CNN.

Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Published Date:

Abstract

Accurate and early diagnosis is critical to proper malaria treatment and hence death prevention. Several computer vision technologies have emerged in recent years as alternatives to traditional microscopy and rapid diagnostic tests. In this work, we used a deep learning model called Mask R-CNN that is trained on uninfected and Plasmodium falciparum-infected red blood cells. Our predictive model produced reports at a rate 15 times faster than manual counting without compromising on accuracy. Another unique feature of our model is its ability to generate segmentation masks on top of bounding box classifications for immediate visualization, making it superior to existing models. Furthermore, with greater standardization, it holds much potential to reduce errors arising from manual counting and save a significant amount of human resources, time, and cost.

Authors

  • De Rong Loh
    Pillar of Information Systems Technology and Design, Singapore University of Technology and Design, Singapore, Singapore. Electronic address: derong_loh@mymail.sutd.edu.sg.
  • Wen Xin Yong
    Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore. Electronic address: wenxin_yong@mymail.sutd.edu.sg.
  • Jullian Yapeter
    Faculty of Engineering, University of Waterloo, Ontario, Canada. Electronic address: jullian.yapeter@uwaterloo.ca.
  • Karupppasamy Subburaj
    Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore. Electronic address: subburaj@sutd.edu.sg.
  • Rajesh Chandramohanadas
    Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore; Department of Microbiology and Immunology, National University of Singapore, Singapore. Electronic address: micrc@nus.edu.sg.