Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead ECG and Help Identify Those at Risk of Atrial Fibrillation-Related Stroke.

Journal: Circulation
Published Date: Feb 16, 2021

Abstract

BACKGROUND: Atrial fibrillation (AF) is associated with substantial morbidity, especially when it goes undetected. If new-onset AF could be predicted, targeted screening could be used to find it early. We hypothesized that a deep neural network could predict new-onset AF from the resting 12-lead ECG and that this prediction may help identify those at risk of AF-related stroke.

Authors

  • Sushravya Raghunath
    Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
  • John M Pfeifer
    Heart and Vascular Center, Evangelical Hospital, Lewisburg, PA, USA.
  • Alvaro E Ulloa-Cerna
    Department of Translational Data Science and Informatics (S.R., A.E.U.-C., L.J., D.P.v.M, J.A.R., N.J.S., G.S., B.K.F., C.M.H.), Geisinger, Danville, PA.
  • Arun Nemani
    Tempus Labs, Inc., Chicago, IL, USA.
  • Tanner Carbonati
    Tempus Labs, Inc., Chicago, IL, USA.
  • Linyuan Jing
    Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania.
  • David P vanMaanen
    Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
  • Dustin N Hartzel
    Phenomic Analytics and Clinical Data Core, Geisinger, Danville, PA, USA.
  • Jeffery A Ruhl
    Department of Translational Data Science and Informatics (S.R., A.E.U.-C., L.J., D.P.v.M, J.A.R., N.J.S., G.S., B.K.F., C.M.H.), Geisinger, Danville, PA.
  • Braxton F Lagerman
    Phenomic Analytics and Clinical Data Core (D.N.H., B.F.L., D.B.R., J.B.L.), Geisinger, Danville, PA.
  • Daniel B Rocha
    Phenomic Analytics and Clinical Data Core (D.N.H., B.F.L., D.B.R., J.B.L.), Geisinger, Danville, PA.
  • Nathan J Stoudt
    Department of Translational Data Science and Informatics (S.R., A.E.U.-C., L.J., D.P.v.M, J.A.R., N.J.S., G.S., B.K.F., C.M.H.), Geisinger, Danville, PA.
  • Gargi Schneider
    Department of Medicine, Geisinger, Danville, Pennsylvania.
  • Kipp W Johnson
  • Noah Zimmerman
    Tempus Labs Inc, Chicago, IL (A.N., T.C., K.W.J., N.Z., A.H.).
  • Joseph B Leader
    Phenomic Analytics and Clinical Data Core, Geisinger, Danville, PA, USA.
  • H Lester Kirchner
    Department of Population Health Sciences, Geisinger, Danville, PA, USA.
  • Christoph J Griessenauer
    Department of Vascular and Endovascular Neurosurgery (C.J.G.), Geisinger, Danville, PA.
  • Ashraf Hafez
    Tempus Labs, Inc., Chicago, IL, USA.
  • Christopher W Good
    Department of Cardiology, Geisinger, Danville, Pennsylvania.
  • Brandon K Fornwalt
    Department of Imaging Science and Innovation, Geisinger, Danville, Pennsylvania; Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky; Department of Radiology, Geisinger, Danville, Pennsylvania. Electronic address: bkf@gatech.edu.
  • Christopher M Haggerty
    IT Data Science, NewYork-Presbyterian Hospital, New York, New York, USA.

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