[Feasibility multi-center study of artificial intelligence assistance in cervical fluid-based cytology diagnosis].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology
Published Date:

Abstract

To propose a method of cervical cytology screening based on deep convolutional neural network and compare it with the diagnosis of cytologists. The deep segmentation network was used to extract 618 333 regions of interest (ROI) from 5, 516 cytological pathological images. Combined with the experience of physicians, the deep classification network with the ability to analyze ROI was trained. The classification results were used to construct features, and the decision model was used to complete the classification of cytopathological images. The sensitivity and specificity were 89.72%, 58.48%, 33.95% and 95.94% respectively. Among the smears derived from four different preparation methods, this algorithm had the best effect on natural fallout with a sensitivity of 91.10%, specificity of 69.32%, positive predictive rate of 41.41%, and negative predictive rate of 97.03%. Deep convolutional neural network image recognition technology can be applied to cervical cytology screening.

Authors

  • J H Lyu
    Department of pathology, Suzhou Municipal Hospital, Suzhou 215002, China.
  • X S Fan
    Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
  • Q Shen
    Radiology (Q.S., J.W.), Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • X X Wang
  • Y F Zhang
    Department of Pathology, Jiangsu Province Hospital of TCM, Nanjing 210029, China.
  • W B Huang
    Department of Pathology, the Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing 210000, China.
  • Y L Cao
    Jiangsu Yitou Health Technology Company, Nanjing 210000, China.
  • C Zhou
    Medical Technology Company, Nanjing 210000, China.
  • J L Chang
    Medical Technology Company, Nanjing 210000, China.
  • W Ma
    Medical Technology Company, Nanjing 210000, China.
  • X J Zhou
    Department of Pathology, Jinling Hospital, Nanjing 210002, China.
  • L H Zhang
    Department of Ultrasonic Medicine, Fetal Medical Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.