Longitudinal machine learning modeling of MS patient trajectories improves predictions of disability progression.

Journal: Computer methods and programs in biomedicine
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: Research in Multiple Sclerosis (MS) has recently focused on extracting knowledge from real-world clinical data sources. This type of data is more abundant than data produced during clinical trials and potentially more informative about real-world clinical practice. However, this comes at the cost of less curated and controlled data sets. In this work we aim to predict disability progression by optimally extracting information from longitudinal patient data in the real-world setting, with a special focus on the sporadic sampling problem.

Authors

  • Edward De Brouwer
    ESAT-STADIUS, KU Leuven, Leuven 3001, Belgium. Electronic address: edward.debrouwer@esat.kuleuven.be.
  • Thijs Becker
    I-Biostat, Data Science Institute, Hasselt University,, Diepenbeek, Belgium.
  • Yves Moreau
    ESAT-STADIUS, KU Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium.
  • Eva Kubala Havrdova
    Charles University in Prague General University Hospital, Prague, Czech.
  • Maria Trojano
    Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy.
  • Sara Eichau
    Hospital Universitario Virgen Macarena, Sevilla, Spain.
  • Serkan Ozakbas
    Dokuz Eylul University, Konak/Izmir, Turkey.
  • Marco Onofrj
    University G. d'Annunzio, Chieti, Italy.
  • Pierre Grammond
    CISSS Chaudire-Appalache, Levis, Canada.
  • Jens Kuhle
    Neurologic Clinic and Policlinic, Multiple Sclerosis (MS) Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Ludwig Kappos
    Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Patrizia Sola
    Azienda Ospedaliera Universitaria, Modena, Italy.
  • Elisabetta Cartechini
    Azienda Sanitaria Unica Regionale Marche - AV3, Macerata, Italy.
  • Jeannette Lechner-Scott
    Hunter Medical Research Institute, New Lambton Heights, NSW, Australia/School of Medicine and Public Health, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia/Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia.
  • Raed Alroughani
    Amiri Hospital, Sharq, Kuwait.
  • Oliver Gerlach
    Zuyderland Ziekenhuis, Sittard, the Netherlands.
  • Tomas Kalincik
    CORe Department of Medicine University of Melbourne Melbourne Australia.
  • Franco Granella
    University of Parma, Parma, Italy.
  • Francois Grand'Maison
    Neuro Rive-Sud, Quebec, Canada.
  • Roberto Bergamaschi
  • Maria José Sá
    Department of Neurology, Centro Hospitalar Universitario de So Joo and University Fernando Pessoa, Porto, Portugal.
  • Bart Van Wijmeersch
    Rehabilitation and MS-Centre Overpelt Hasselt University, Hasselt, Belgium.
  • Aysun Soysal
    Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey.
  • Jose Luis Sanchez-Menoyo
    Hospital de Galdakao-Usansolo, Galdakao, Spain.
  • Claudio Solaro
    Dept of Rehabilitation mons L Novarese Hospital, Moncrivello, Italy.
  • Cavit Boz
    KTU Medical Faculty Farabi Hospital, Trabzon, Turkey.
  • Gerardo Iuliano
    previously at Ospedali Riuniti di Salerno, Salerno, Italy.
  • Katherine Buzzard
    Box Hill Hospital, Melbourne, Australia.
  • Eduardo Aguera-Morales
    University Hospital Reina Sofia, Cordoba, Spain.
  • Murat Terzi
    19 Mayis University, Samsun, Turkey.
  • Tamara Castillo Trivio
    Hospital Universitario Donostia, San Sebastain, Spain.
  • Daniele Spitaleri
    Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italy.
  • Vincent Van Pesch
    Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Vahid Shaygannejad
    Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Fraser Moore
    Jewish General Hospital, Montreal, Canada.
  • Celia Oreja-Guevara
    Hospital Clinico San Carlos, Madrid, Spain.
  • Davide Maimone
    Garibaldi Hospital, Catania, Italy.
  • Riadh Gouider
    Razi Hospital, Manouba, Tunisia.
  • Tunde Csepany
    University of Debrecen, Debrecen, Hungary.
  • Cristina Ramo-Tello
    Hospital Germans Trias i Pujol, Badalona, Spain.
  • Liesbet Peeters
    I-Biostat, Data Science Institute, Hasselt University, Diepenbeek, Belgium; Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek 3590, Belgium; Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek 3590, Belgium; I-Biostat, Data Science Institute, Hasselt University, Diepenbeek, Belgium. Electronic address: liesbet.peeters@uhasselt.be.