BACKGROUND AND OBJECTIVES: The brain-predicted age difference (brain-PAD) is a novel marker of neurodegeneration in multiple sclerosis (MS). Brain-PAD has been associated with clinical disability in heterogeneous MS patient cohorts of varying ages an...
Biochemical and biophysical research communications
Dec 16, 2025
BACKGROUND: Multiple sclerosis (MS) and psoriasis are both immune-mediated inflammatory diseases. Previous studies have reported comorbidity between MS and psoriasis, but the underlying mechanisms remain unclear. This study aims to elucidate the shar...
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory brain lesions, making MRI-based lesion segmentation challenging due to noise, missing data, and limited availability of high-quality labeled images. This paper pres...
Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are debilitating diseases with unpredictable progression. Artificial Intelligence-based tools for modelling disease progression could significantly improve the quality of life for patien...
BACKGROUND AND OBJECTIVES: High-dose methylprednisolone (MP) is the global standard for treating pregnancy-associated relapses in multiple sclerosis (MS). Given that glucocorticoids cross the placenta and may interfere with fetal brain development, c...
This study presents an automated system using Convolutional Neural Networks (CNNs) for segmenting FLAIR Magnetic Resonance Imaging (MRI) images to aid in the diagnosis of Multiple Sclerosis (MS). The dataset included 103 patients from Imam Khomeini H...
BACKGROUND AND OBJECTIVES: Retinal alterations in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) remain unclear, especially the specific patterns and extent of microvascular change. This study aimed to compare these altera...
PURPOSE: Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substant...
OBJECTIVE: To investigate the causal relationship between serotonin levels, adenosine deaminase (ADA) activity and multiple sclerosis (MS) progression using an integrative multi-omics approach.
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is common in adults while myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is rare. Our previous machine-learning algorithm, using clinical variables, ≤6 brain lesions, and no ...
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