Delayed brain development of Rolandic epilepsy profiled by deep learning-based neuroanatomic imaging.

Journal: European radiology
Published Date:

Abstract

OBJECTIVES: Although Rolandic epilepsy (RE) has been regarded as a brain developmental disorder, neuroimaging studies have not yet ascertained whether RE has brain developmental delay. This study employed deep learning-based neuroanatomic biomarker to measure the changed feature of "brain age" in RE.

Authors

  • Qirui Zhang
    Department of Medical Imaging, Jinling Hospital, Southern Medical University, No.305, Zhongshan East Road, Nanjing, 210002, China.
  • Yan He
    School of Biology & Engineering, Guizhou Medical University, Guiyang, Guizhou Province, China.
  • Taiping Qu
    Deepwise AI Lab, Deepwise Inc., Beijing, China.
  • Fang Yang
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, People's Republic of China.
  • Ying Lin
    Clinical Laboratory, Dongzhimen Hospital Affiliated to BUCM, Beijing, China.
  • Zheng Hu
    Department of Obstetrics and Gynecology, Precision Medicine Institute, Sun Yat-sen University, Yuexiu, Guangzhou, Guangdong, China.
  • Xiuli Li
    Department of Obstetrics and Gynecology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
  • Qiang Xu
    University of Huddersfield, Queensgate, Huddersfield, United Kingdom . Electronic address: Q.Xu2@hud.ac.uk.
  • Wei Xing
    Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou Jiangsu 213003.
  • Valentina Gumenyuk
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Steven M Stufflebeam
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Hesheng Liu
    Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. hesheng.liu@mgh.harvard.edu.
  • Guangming Lu
    Department of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, China.
  • Zhiqiang Zhang
    Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.