An improved DNA-binding hot spot residues prediction method by exploring interfacial neighbor properties.

Journal: BMC bioinformatics
Published Date: May 17, 2021

Abstract

BACKGROUND: DNA-binding hot spots are dominant and fundamental residues that contribute most of the binding free energy yet accounting for a small portion of protein-DNA interfaces. As experimental methods for identifying hot spots are time-consuming and costly, high-efficiency computational approaches are emerging as alternative pathways to experimental methods.

Authors

  • Sijia Zhang
    Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui, China.
  • Lihua Wang
    Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
  • Le Zhao
  • Menglu Li
    School of Computer Science and Technology, Anhui University, Hefei, Anhui 230601, China.
  • Mengya Liu
    Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui, China.
  • Ke Li
    School of Ideological and Political Education, Shanghai Maritime University, Shanghai, China.
  • Yannan Bin
    Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
  • Junfeng Xia

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