[Application of neural network autoencoder algorithm in the cancer informatics research].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Published Date:

Abstract

Cancers have been widely recognized as highly heterogeneous diseases, and early diagnosis and prognosis of cancer types have become the focus of cancer research. In the era of big data, efficient mining of massive biomedical data has become a grand challenge for bioinformatics research. As a typical neural network model, the autoencoder is able to efficiently learn the features of input data by unsupervised training method and further help integrate and mine the biological data. In this article, the primary structure and workflow of the autoencoder model are introduced, followed by summarizing the advances of the autoencoder model in cancer informatics using various types of biomedical data. Finally, the challenges and perspectives of the autoencoder model are discussed.

Authors

  • Xiao Li
    Department of Inner Mongolia Clinical Medicine College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
  • Jie Ma
    Respiratory Department, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China.
  • Fuchu He
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
  • Yunping Zhu
    Beijing Institute of Lifeomics, Beijing 102206, China.