A comprehensive comparison of residue-level methylation levels with the regression-based gene-level methylation estimations by ReGear.
Journal:
Briefings in bioinformatics
Published Date:
Jul 20, 2021
Abstract
MOTIVATION: DNA methylation is a biological process impacting the gene functions without changing the underlying DNA sequence. The DNA methylation machinery usually attaches methyl groups to some specific cytosine residues, which modify the chromatin architectures. Such modifications in the promoter regions will inactivate some tumor-suppressor genes. DNA methylation within the coding region may significantly reduce the transcription elongation efficiency. The gene function may be tuned through some cytosines are methylated.