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Models, Genetic

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[Development of prognostic clinical and genetic models of the risk of low bone mineral density using neural network training].

Problemy endokrinologii
BACKGROUND: Osteoporosis is a common age-related disease with disabling consequences, the early diagnosis of which is difficult due to its long and hidden course, which often leads to diagnosis only after a fracture. In this regard, great expectation...

Comparing statistical learning methods for complex trait prediction from gene expression.

PloS one
Accurate prediction of complex traits is an important task in quantitative genetics. Genotypes have been used for trait prediction using a variety of methods such as mixed models, Bayesian methods, penalized regression methods, dimension reduction me...

The role of chromatin state in intron retention: A case study in leveraging large scale deep learning models.

PLoS computational biology
Complex deep learning models trained on very large datasets have become key enabling tools for current research in natural language processing and computer vision. By providing pre-trained models that can be fine-tuned for specific applications, they...

A compendium of human gene functions derived from evolutionary modelling.

Nature
A comprehensive, computable representation of the functional repertoire of all macromolecules encoded within the human genome is a foundational resource for biology and biomedical research. The Gene Ontology Consortium has been working towards this g...

WheatGP, a genomic prediction method based on CNN and LSTM.

Briefings in bioinformatics
Wheat plays a crucial role in ensuring food security. However, its complex genetic structure and trait variation pose significant challenges for breeding superior varieties. In this study, a genomic prediction method for wheat (WheatGP) is proposed. ...

Genomic selection in pig breeding: comparative analysis of machine learning algorithms.

Genetics, selection, evolution : GSE
BACKGROUND: The effectiveness of genomic prediction (GP) significantly influences breeding progress, and employing SNP markers to predict phenotypic values is a pivotal aspect of pig breeding. Machine learning (ML) methods are usually used to predict...

Exploring the application of deep learning methods for polygenic risk score estimation.

Biomedical physics & engineering express
. Polygenic risk scores (PRS) summarise genetic information into a single number with clinical and research uses. Deep learning (DL) has revolutionised multiple fields, however, the impact of DL on PRSs has been less significant. We explore how DL ca...

Sweet pepper yield modeling via deep learning and selection of superior genotypes using GBLUP and MGIDI.

Scientific reports
Intelligent knowledge about Capsicum annuum L. germplasm could lead to effective management of germplasm. Here, 29 accessions of sweet pepper were investigated in two separate randomized complete block design with three replications in the field cond...

EBMGP: a deep learning model for genomic prediction based on Elastic Net feature selection and bidirectional encoder representations from transformer's embedding and multi-head attention pooling.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Enhancing early selection through genomic estimated breeding values is pivotal for reducing generation intervals and accelerating breeding programs. Recently, deep learning (DL) approaches have gained prominence in genomic prediction (GP). Here, we i...

Phyloformer: Fast, Accurate, and Versatile Phylogenetic Reconstruction with Deep Neural Networks.

Molecular biology and evolution
Phylogenetic inference aims at reconstructing the tree describing the evolution of a set of sequences descending from a common ancestor. The high computational cost of state-of-the-art maximum likelihood and Bayesian inference methods limits their us...