Development and Validation of the Automated Imaging Differentiation in Parkinsonism (AID-P): A Multi-Site Machine Learning Study.

Journal: The Lancet. Digital health
Published Date:

Abstract

BACKGROUND: There is a critical need to develop valid, non-invasive biomarkers for Parkinsonian syndromes. The current 17-site, international study assesses whether non-invasive diffusion MRI (dMRI) can distinguish between Parkinsonian syndromes.

Authors

  • Derek B Archer
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Justin T Bricker
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Winston T Chu
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Roxana G Burciu
    Department of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, DE.
  • Johanna L Mccracken
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Song Lai
    Department of Radiation Oncology & CTSI Human Imaging Core, University of Florida, Gainesville, FL.
  • Stephen A Coombes
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Ruogu Fang
    J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.
  • Angelos Barmpoutis
    J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.
  • Daniel M Corcos
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
  • Ajay S Kurani
    Department of Radiology, Northwestern University, Chicago, IL.
  • Trina Mitchell
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Mieniecia L Black
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.
  • Ellen Herschel
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Tanya Simuni
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Todd B Parrish
    Department of Radiology, Northwestern University, Chicago, IL.
  • Cynthia Comella
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
  • Tao Xie
    Department of Neurology, University of Chicago Medicine, Chicago, IL.
  • Klaus Seppi
    Department of Neurology, Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
  • Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI.
  • Martijn L T M Müller
    Department of Radiology, University of Michigan, Ann Arbor, MI.
  • Roger L Albin
    Department of Neurology, University of Michigan, Ann Arbor, MI.
  • Florian Krismer
    Department of Neurology, Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.
  • Guangwei Du
    Department of Neurology, Penn State - Milton S. Hershey Medical Center, Hershey, PA.
  • Mechelle M Lewis
    Department of Neurology, Penn State - Milton S. Hershey Medical Center, Hershey, PA.
  • Xuemei Huang
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
  • Hong Li
    Department of Public Health Sciences, Medical College of South Carolina, Charleston, SC.
  • Ofer Pasternak
    Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Nikolaus R McFarland
    Fixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL.
  • Michael S Okun
    Fixel Institute for Neurological Disease, College of Medicine, University of Florida, Gainesville, FL.
  • David E Vaillancourt
    Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.