The AlphaFold Database of Protein Structures: A Biologist's Guide.

Journal: Journal of molecular biology
Published Date: Oct 29, 2021

Abstract

AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology.

Authors

  • Alessia David
    Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London SW7 2AZ, UK.
  • Suhail Islam
    Centre for Integrative System Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
  • Evgeny Tankhilevich
    Centre for Integrative System Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
  • Michael J E Sternberg
    Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London SW7 2AZ, UK.

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