Training, Validation, and Test of Deep Learning Models for Classification of Receptor Expressions in Breast Cancers From Mammograms.

Journal: JCO precision oncology
PMID: 34994603

Abstract

PURPOSE: The molecular subtype of breast cancer is an important component of establishing the appropriate treatment strategy. In clinical practice, molecular subtypes are determined by receptor expressions. In this study, we developed a model using deep learning to determine receptor expressions from mammograms.

Authors

  • Daiju Ueda
    Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. ai.labo.ocu@gmail.com.
  • Akira Yamamoto
    From the Department of Diagnostic and Interventional Radiology (D.U., A.Y., T.S., S.D., A.S., Y.M.) and Department of Premier Preventive Medicine (S.F.), Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan; LPixel, Tokyo, Japan (M.N., A.C., Y.S.); and Department of Radiology, Osaka City University Hospital, Osaka, Japan (Y.K.).
  • Tsutomu Takashima
  • Naoyoshi Onoda
    Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
  • Satoru Noda
    Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
  • Shinichiro Kashiwagi
    Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
  • Tamami Morisaki
    Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
  • Takashi Honjo
    Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
  • Akitoshi Shimazaki
    From the Department of Diagnostic and Interventional Radiology (D.U., A.Y., T.S., S.D., A.S., Y.M.) and Department of Premier Preventive Medicine (S.F.), Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan; LPixel, Tokyo, Japan (M.N., A.C., Y.S.); and Department of Radiology, Osaka City University Hospital, Osaka, Japan (Y.K.).
  • Yukio Miki
    Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

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