Increasing the accuracy of single sequence prediction methods using a deep semi-supervised learning framework.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: Over the past 50 years, our ability to model protein sequences with evolutionary information has progressed in leaps and bounds. However, even with the latest deep learning methods, the modelling of a critically important class of proteins, single orphan sequences, remains unsolved.

Authors

  • Lewis Moffat
    Department of Computer Science, University College London, London, UK.
  • David T Jones
    Department of Computer Science, Bioinformatics Group, University College London, Gower Street, London, WC1E 6BT, United Kingdom. d.t.jones@ucl.ac.uk.