On-site testing of multiple drugs of abuse in urine by a miniature dual-LIT mass spectrometer.

Journal: Analytica chimica acta
PMID: 32029121

Abstract

There is an increasing need for rapid and on-site detection of emerging drugs of abuse. In this work, we developed a method using a miniature dual-LIT (linear ion trap) mass spectrometer recently developed with comprehensive tandem mass spectrometry analysis capability, for qualitative and quantitative analysis of multiple drugs of abuse. Paper-capillary spray cartridges were used with related workflow established to simplify overall analysis procedure. Quantitation of ketamine and methamphetamine was achieved by beam-type collision-induced dissociation on the miniature dual-LIT mass spectrometer and a linear concentration range of 100-5000 ng/mL was obtained. The system has been applied in analysis of real urine samples from individuals addicted to morphine and methamphetamine use. The changes of the ratio of cocaine to its metabolite benzoylecgonine were also explored to estimate the time of cocaine intaking.

Authors

  • Manqing Kang
    State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, 100084, Beijing, China.
  • Wanru Zhang
    PURSPEC Technologies, Inc, 33 Shuangqing Road, 100084, Beijing, China.
  • Linpei Dong
    Institute of Forensic Science, Ministry of Public Security, 100038, Beijing, China.
  • Xinxin Ren
    Institute of Forensic Science, Ministry of Public Security, 100038, Beijing, China.
  • Yin Zhu
    Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang Province, 314006, China.
  • Zhenhua Wang
    Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang Province, 314006, China.
  • Lijun Liang
    Public Security Bureau of Jiaxing City, Zhejiang Province, 314000, China.
  • Jinfeng Xue
    Public Security Bureau of Jiaxing City, Zhejiang Province, 314000, China.
  • Yunfeng Zhang
    Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
  • Wenpeng Zhang
    State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, 100084, Beijing, China; Department of Chemistry, Purdue University, West Lafayette, IN, 47906, USA. Electronic address: zhan2360@purdue.edu.
  • Zheng Ouyang
    State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, 100084, Beijing, China; Department of Chemistry, Purdue University, West Lafayette, IN, 47906, USA. Electronic address: ouyang@tsinghua.edu.cn.

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