Automatic Placenta Localization From Ultrasound Imaging in a Resource-Limited Setting Using a Predefined Ultrasound Acquisition Protocol and Deep Learning.

Journal: Ultrasound in medicine & biology
PMID:

Abstract

Placenta localization from obstetric 2-D ultrasound (US) imaging is unattainable for many pregnant women in low-income countries because of a severe shortage of trained sonographers. To address this problem, we present a method to automatically detect low-lying placenta or placenta previa from 2-D US imaging. Two-dimensional US data from 280 pregnant women were collected in Ethiopia using a standardized acquisition protocol and low-cost equipment. The detection method consists of two parts. First, 2-D US segmentation of the placenta is performed using a deep learning model with a U-Net architecture. Second, the segmentation is used to classify each placenta as either normal or a class including both low-lying placenta and placenta previa. The segmentation model was trained and tested on 6574 2-D US images, achieving a median test Dice coefficient of 0.84 (interquartile range = 0.23). The classifier achieved a sensitivity of 81% and a specificity of 82% on a holdout test set of 148 cases. Additionally, the model was found to segment in real time (19 ± 2 ms per 2-D US image) using a smartphone paired with a low-cost 2-D US device. This work illustrates the feasibility of using automated placenta localization in a resource-limited setting.

Authors

  • Martijn Schilpzand
    Diagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands; Medical Ultrasound Imaging Centre, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands; Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands. Electronic address: Martijn.sch@gmail.com.
  • Chase Neff
    Medical Ultrasound Imaging Centre, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Jeroen van Dillen
    Department of Obstetrics, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Bram van Ginneken
    Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Fraunhofer Mevis, Bremen, Germany.
  • Tom Heskes
    Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands.
  • Chris de Korte
    Medical Ultrasound Imaging Centre, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands; Physics of Fluids Group, Technical Medical Center, University of Twente, Enschede, The Netherlands.
  • Thomas van den Heuvel
    Diagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands; Medical Ultrasound Imaging Centre, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.