Developing a Data Driven Approach for Early Detection of SIRS in Pediatric Intensive Care Using Automatically Labeled Training Data.

Journal: Studies in health technology and informatics
Published Date:

Abstract

Critical care can benefit from analyzing data by machine learning approaches for supporting clinical routine and guiding clinical decision-making. Developing data-driven approaches for an early detection of systemic inflammatory response syndrome (SIRS) in patients of pediatric intensive care and exploring the possibility of an approach using training data sets labeled automatically beforehand by knowledge-based approaches rather than clinical experts. Using naïve Bayes classifier and an artificial neuronal network (ANN), trained with real data labeled by (1) domain experts ad (2) a knowledge-based decision support system (CDSS). Accuracies were evaluated by the data set labeled by domain experts using a 10-fold cross validation. The ANN approach trained with data labeled by domain experts yielded a specificity of 0.9139 and sensitivity of 0.8979, whereas the approach trained with a data set labeled by a knowledge-based CDSS achieves a specificity of 0.9220 and a sensitivity of 0.8887. ANN yielded promising results for data-driven detection of pediatric SIRS with real data. Our comparison shows the feasibility of using training data labeled automatically by knowledge-based approaches rather than manually allocated by experts.

Authors

  • Marcel Mast
    Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School, Hannover, Germany.
  • Michael Marschollek
  • Thomas Jack
    Department of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School.
  • Antje Wulff
    Peter L. Reichertz Institute for Medical Informatics, University of Braunschweig and Hannover Medical School, Germany.