The importance of multi-modal imaging and clinical information for humans and AI-based algorithms to classify breast masses (INSPiRED 003): an international, multicenter analysis.

Journal: European radiology
Published Date: Feb 17, 2022

Abstract

OBJECTIVES: AI-based algorithms for medical image analysis showed comparable performance to human image readers. However, in practice, diagnoses are made using multiple imaging modalities alongside other data sources. We determined the importance of this multi-modal information and compared the diagnostic performance of routine breast cancer diagnosis to breast ultrasound interpretations by humans or AI-based algorithms.

Authors

  • André Pfob
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Chris Sidey-Gibbons
    MD Anderson Center for INSPiRED Cancer Care, University of Texas, Houston, TX, United States.
  • Richard G Barr
    Northeastern Ohio Medical University, Youngstown, OH.
  • Volker Duda
    Department of Gynecology and Obstetrics, University of Marburg, Marburg, Germany.
  • Zaher Alwafai
    Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany.
  • Corinne Balleyguier
    Department of Radiology, Gustave Roussy Cancer Campus, Villejuif, France; Université Paris-Saclay, Paris, France.
  • Dirk-André Clevert
    Department of Radiology, University Hospital Munich-Grosshadern, Munich, Germany.
  • Sarah Fastner
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Christina Gomez
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Manuela Goncalo
    Department of Radiology, University of Coimbra, Coimbra, Portugal.
  • Ines Gruber
    Department of Gynecology and Obstetrics, University of Tuebingen, Tuebingen, Germany.
  • Markus Hahn
    Department of Gynecology and Obstetrics, University of Tuebingen, Tuebingen, Germany.
  • André Hennigs
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Panagiotis Kapetas
    Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image-Guided Therapy.
  • Sheng-Chieh Lu
    MD Anderson Center for INSPiRED Cancer Care (Integrated Systems for Patient-Reported Data), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Juliane Nees
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Ralf Ohlinger
    Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany.
  • Fabian Riedel
    Department of Gynecology and Obstetrics, Heidelberg University Hospital, Heidelberg, Germany.
  • Matthieu Rutten
    From the Diagnostic Image Analysis Group, Radboud University Medical Center, Geert Groteplein 10, Nijmegen 6500 HB, the Netherlands (K.M., E.T.S., S.S., C.M.S., B.v.G.); Department of Radiology, Bernhoven Hospital, Uden, the Netherlands (H.S.); Department of Radiology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands (A.J.G.K., M.B.J.M.K., T.S., M.R.); Department of Radiology, Meander Medisch Centrum, Amersfoort, the Netherlands (C.M.S.); and Thirona, Nijmegen, the Netherlands (R.H.H.M.P., A.M., J.M.).
  • Benedikt Schaefgen
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Maximilian Schuessler
    National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
  • Anne Stieber
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Riku Togawa
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Mitsuhiro Tozaki
    Department of Radiology, Sagara Hospital, 3-31 Matsubara-cho, Kagoshima City, Kagoshima, 892-0833, Japan.
  • Sebastian Wojcinski
    Department of Gynecology and Obstetrics, Breast Cancer Center, Klinikum Bielefeld Mitte GmbH, Bielefeld, Germany.
  • Cai Xu
    MD Anderson Center for INSPiRED Cancer Care (Integrated Systems for Patient-Reported Data), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Geraldine Rauch
    Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin , Germany.
  • Joerg Heil
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Michael Golatta
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Michael.golatta@med.uni-heidelberg.de.

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