Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art.

Journal: Chemico-biological interactions
PMID:

Abstract

Artificial intelligence (AI) and machine learning models are today frequently used for classification and prediction of various biochemical processes and phenomena. In recent years, numerous research efforts have been focused on developing such models for assessment, categorization, and prediction of oxidative stress. Supervised machine learning can successfully automate the process of evaluation and quantification of oxidative damage in biological samples, as well as extract useful data from the abundance of experimental results. In this concise review, we cover the possible applications of neural networks, decision trees and regression analysis as three common strategies in machine learning. We also review recent works on the various weaknesses and limitations of artificial intelligence in biochemistry and related scientific areas. Finally, we discuss future innovative approaches on the ways how AI can contribute to the automation of oxidative stress measurement and diagnosis of diseases associated with oxidative damage.

Authors

  • Igor Pantic
    University of Belgrade, Faculty of Medicine, Institute of Medical Physiology, Laboratory for Cellular Physiology, Visegradska 26/II, RS-11129, Belgrade, Serbia; University of Haifa, 199 Abba Hushi Blvd. Mount Carmel, Haifa, IL-3498838, Israel. Electronic address: igorpantic@gmail.com.
  • Jovana Paunovic
    University of Belgrade, Faculty of Medicine, Institute of Pathological Physiology, Dr Subotica 9, RS-11129, Belgrade, Serbia.
  • Snezana Pejic
    University of Belgrade, Vinca Institute of Nuclear Sciences, Department of Molecular Biology and Endocrinology, Mike Petrovica Alasa 12-14, RS-11351, Belgrade, Serbia.
  • Dunja Drakulic
    University of Belgrade, Vinca Institute of Nuclear Sciences, Department of Molecular Biology and Endocrinology, Mike Petrovica Alasa 12-14, RS-11351, Belgrade, Serbia.
  • Ana Todorovic
    University of Belgrade, Vinca Institute of Nuclear Sciences, Department of Molecular Biology and Endocrinology, Mike Petrovica Alasa 12-14, RS-11351, Belgrade, Serbia.
  • Sanja Stankovic
    Centre of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
  • Danijela Vucevic
    University of Belgrade, Faculty of Medicine, Institute of Pathological Physiology, Dr Subotica 9, RS-11129, Belgrade, Serbia.
  • Jelena Cumic
    University of Belgrade, Faculty of Medicine, Clinical Center of Serbia, Dr. Koste Todorovića 8, RS-11129, Belgrade, Serbia.
  • Tatjana Radosavljevic
    University of Belgrade, Faculty of Medicine, Institute of Pathological Physiology, Dr Subotica 9, RS-11129, Belgrade, Serbia.