Speeding up the Topography Imaging of Atomic Force Microscopy by Convolutional Neural Network.

Journal: Analytical chemistry
Published Date:

Abstract

Atomic force microscopy (AFM) provides unprecedented insight into surface topography research with ultrahigh spatial resolution at the subnanometer level. However, a slow scanning rate has to be employed to ensure the image quality, which will largely increase the accumulated sample drift, thereby, resulting in the low fidelity of the AFM image. In this paper, we propose a fast imaging method which performs a complete fast Raster scanning and a slow μ-path subsampling together with a deep learning algorithm to rapidly produce an AFM image with high quality and small drift. A supervised convolutional neural network (CNN) model is trained with the slow μ-path subsampled data and its counterpart acquired with fast Raster scan. The fast speed acquired AFM image is then inputted to the well-trained CNN model to output the high quality one. We validate the reliability of this method using a silicon grids sample and further apply it to the fast imaging of a vanadium dioxide thin film. The results demonstrate that this method can largely improve the imaging speed up to 10.3 times with state-of-the-art imaging quality, and reduce the sample drift by 8.9 times in the multiframe AFM imaging of the same area. Furthermore, we prove that this method is also applicable to other scanning imaging techniques such as scanning electrochemical microscopy.

Authors

  • Peng Zheng
    Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
  • Hao He
    School of Aerospace Engineering , Xiamen University , Xiamen 361005 , P. R. China.
  • Yun Gao
    The Cancer Research Institute, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China.
  • Peiwen Tang
    College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
  • Hailong Wang
    Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Juan Peng
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
  • Lei Wang
    Department of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Chanmin Su
    Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
  • Songyuan Ding
    College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.