Precision measurement of cardiac structure and function in cardiovascular magnetic resonance using machine learning.

Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Published Date:

Abstract

BACKGROUND: Measurement of cardiac structure and function from images (e.g. volumes, mass and derived parameters such as left ventricular (LV) ejection fraction [LVEF]) guides care for millions. This is best assessed using cardiovascular magnetic resonance (CMR), but image analysis is currently performed by individual clinicians, which introduces error. We sought to develop a machine learning algorithm for volumetric analysis of CMR images with demonstrably better precision than human analysis.

Authors

  • Rhodri H Davies
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • João B Augusto
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Anish Bhuva
    Institute for Cardiovascular Science, University College London, United Kingdom
  • Hui Xue
    Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
  • Thomas A Treibel
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Yang Ye
    Wuxi Hospital of Traditional Chinese Medicine, Wuxi, China.
  • Rebecca K Hughes
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Wenjia Bai
    Department of Computing Imperial College London London UK.
  • Clement Lau
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Hunain Shiwani
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK.
  • Marianna Fontana
    Institute of Cardiovascular Science, University College London, United Kingdom (K.D.K., A.S., J.B.A., L.C., C.M., A.N.B., T.K., C.V.B., R.H.D., M.F., J.C.M.).
  • Rebecca Kozor
    Sydney Medical School, University of Sydney, Sydney, Australia.
  • Anna Herrey
    Bart's Heart Centre, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
  • Luís R Lopes
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Viviana Maestrini
    Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
  • Stefania Rosmini
    Barts Heart Center, The Cardiovascular Magnetic Resonance Imaging Unit and The Inherited Cardiovascular Diseases Unit, St. Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
  • Steffen E Petersen
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (H.X., P.K.).
  • Daniel Rueckert
    Biomedical Image Analysis (BioMedIA) Group, Department of Computing, Imperial College London, UK. Electronic address: d.rueckert@imperial.ac.uk.
  • John P Greenwood
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, and Leeds Teaching Hospitals NHS Trust, UK.
  • Gabriella Captur
    Institute of Cardiovascular Science, University College London, London, UK.
  • Charlotte Manisty
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Erik Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cardiovascular Magnetic Resonance Center, UPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • James C Moon
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK. Electronic address: j.moon@ucl.ac.uk.