Magnetically Actuated Cell-Robot System: Precise Control, Manipulation, and Multimode Conversion.

Journal: Small (Weinheim an der Bergstrasse, Germany)
PMID: 35233944

Abstract

Border-nearing microrobots with self-propelling and navigating capabilities have promising applications in micromanipulation and bioengineering, because they can stimulate the surrounding fluid flow for object transportation. However, ensuring the biosafety of microrobots is a concurrent challenge in bioengineering applications. Here, macrophage template-based microrobots (cell robots) that can be controlled individually or in chain-like swarms are proposed, which can transport various objects. The cell robots are constructed using the phagocytic ability of macrophages to load nanomagnetic particles while maintaining their viability. The robots exhibit high position control accuracy and generate a flow field that can be used to transport microspheres and sperm when exposed to an external magnetic field near a wall. The cell robots can also form chain-like swarms to transport a large object (more than 100 times the volume). This new insight into the manipulation of macrophage-based cell robots provides a new concept by converting other biological cells into microrobots for micromanipulation in biomedical applications.

Authors

  • Yuguo Dai
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Lina Jia
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Luyao Wang
    Department of Genetics, School of Life Sciences, Bengbu Medical University, Bengbu, China.
  • Hongyan Sun
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Yiming Ji
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Chutian Wang
    School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
  • Li Song
    Department of Obstetrics and Gynecology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan Shandong China.
  • Shuzhang Liang
    School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
  • Dixiao Chen
    School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
  • Yanmin Feng
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Xue Bai
    School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
  • Deyuan Zhang
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Fumihito Arai
    Department of Micro-Nano Mechanical Science and Engineering, Nagoya University, Nagoya, Aichi, Japan. arai@mech.nagoya-u.ac.jp.
  • Huawei Chen
    School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
  • Lin Feng
    Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Sichuan 611130, China.

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